|
How does MyoRx work?
Omega based compounds have been used in the treatment of
inflammation and heart disease. There are several hundred
articles in the medical literature documenting the biological
and medicinal properties of the omega compounds. Clinical
studies were performed at major medical schools in the U.S.
and abroad proving the benefits and safety of these compounds.
These oils work by manipulating the inflammatory process within
the cells. Omega 3 has been shown in clinical trials to suppress
the production of specific prostaglandins and leukotrienes,
which are the agents of inflammation.
Immunobiology
To address the question of how MyoRx works, we can extrapolate
from more than two decades of research and several hundred
papers on the cellular effects of the omega-3 and omega-6
fatty acids. At the sites of tissue injury, immune cells create
inflammation in an effort to heal the injury. When immune
cells get "turned on" to produce inflammation and inflammatory
messenger molecules, the eicosanoids, the principle fatty
acid in the cell envelope, arachidonic acid catalyzes this
transformation and can be metabolized into activated eicosanoids
such as prostaglandins and leukotrienes. If the cell is exposed
to omega-3 and omega-6 fatty acids, they displace some of
the arachidonic acid in the cell envelope. Then if the cell
is exposed to tissue injury, signaling to the cell interior
via the alternative fatty acids does not lead to transformation
of the cell to an "armed" cell -- rather it remains "neutral."
Furthermore, the prostaglandins and leukotrienes derived from
these alternative fatty acids are not inflammatory in nature.
The end result is a "dampening-down" of the inflammatory process,
with less pain, swelling, and other signs of inflammation,
but without impairment of normal tissue repair. Other similar
inflammation and pain-modulating effects have been demonstrated,
and there may be effects that we don't yet recognize. For
example, it is striking how quickly MyoRx can work to improve
pain and swelling quicker than might be expected from the
above-described mechanism of action. Could these fatty acids
have a beneficial effect on the nerve pathways that transmit
pain? A clue to this possibility lies in the response of neurotransmitter
function. Further studies will illuminate if MyoRx directly
affects pain pathways as well as down-regulating inflammation.
| Effects on intracellular
signal transduction pathways |
|
Effect
Decreased monocyte production of IL-1, IL-2, TNF
Decreased leucocyte chemotaxis
Decreased endothelial permeability
Increase in endothelial-dependent vasodilatation
Eicosanoid-independent inhibition of platelet function
Decreased enothelial PDGF
|
Consequence
Immune system down-regulation:
Anti-inflammation
Anti-aggregation
Vasodilation
Anti-adhesion
|
Why does MyoRx work?
The omega oils cause enhanced absorption through the skin
and into deeper tissues allowing greater delivery of medicine
to the muscles and joints.
Why not take Omega 3 orally?
Massive oral doses of Omega 3 are needed to decrease inflammation.
High levels of this fatty acid add significant calories to
the diet and can cause gastrointestinal disturbance. By applying
Omega 3 cream topically, patients and athletes benefit from
the anti-inflammatory properties without the side effects
of weight gain and stomach discomfort.
|
